Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics’
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چکیده
منابع مشابه
Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics'
A major obstacle to the efficient production of antibody conjugates for therapy and diagnosis is the non-ideal performance of commonly used chemical methods for the attachment of effector-molecules to the antibody of interest. Here we demonstrate that this limitation can be simply addressed using 3,4-substituted maleimides to bridge and thus functionalize disulfide bonds to generate homogeneous...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2013
ISSN: 2045-2322
DOI: 10.1038/srep01525